The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
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Cortisol derived from glucocorticoid (steroid hormone) produced by the adrenal glands.

See how emotions affect the adrenal glands.

High Cortisol may cause chronic fatigue, sleepiness, mood changes, inability to lose weight, diabetes, depression, sex hormone changes and inability to cope with stress. Cortisol increases and DHEA decreases as we age.

The pharm cure for high cortisol are MAOI drugs, numerous physicians are reporting they harm the mind and body and can even cause manic episodes for some with Bi Polar depression.

Items listed in the scientific reports below are reported to lower Cortisol.
See report #
Xian Mao english name is Golden eye grass rhizone.
Wild Indigo
Green Tea.
Magnolia bark
Phellodendron bark

Huffington Post "Cortisol is a stress hormone designed to give us the bursts of energy needed to escape a dangerous situation, like running away from a tiger. Unfortunately, modern life often convinces our brains that everything is a stressful situation -- and it's nearly impossible to escape an overflowing inbox. Instead of resolving the issue, we stay on high alert all the time, with elevated blood pressure and glucose levels. Over time, this becomes a serious health issue, despite how conventional medicine neglects the importance of this bad-boy hormone -- and that's not just my opinion, but the evidence continues to mount."

Elevated cortisol levels can affect energy, stress, thyroid, adrenal glands increasing anxiousness irritability and stress, weight gain, bone loss, contribute to diabetes and heart disease risk.

Cortisol is known as the aging hormone. High cortisol causes a “fight or flight” response which stimulates your sympathetic nervous system and adrenal glands resulting in a decrease of digestive secretions and a increase in blood pressure.

The scientific formula to lower cortisol is to inhibit the activity of monoamine oxidase in the hypothalamus.

1. "Monoamine oxidase inhibitors (MAOIs) are chemicals which inhibit the activity of the monoamine oxidase enzyme family. They have a long history of use as medications prescribed for the treatment of depression. They are particularly effective in treating atypical depression.[1] They are also used in the treatment of Parkinson's Disease and several other disorders." Authors note: There are numerous reports that the pharmicutical MAOI's have detremintal effects on the mind and body. Below are research reports of natural things reported to lower cortisol and monoamine oxidase.

2. "CONCLUSION:CYP3A enzymatic activity and CYP3A4 protein expression (high cortisol) could be inhibited by Xian Mao." Xian Mao english name is Golden eye grass rhizone.

3. "...The data also show, albeit to a lesser extent, inhibitory properties of herbs originating from the mint family (Lamiaceae) and Turmeric, Comfrey, Bringraj, Skullcap, Kava-kava, Wild Indigo, Gentian and Green Tea. In conclusion, the data reflect relative potency information by rank of commonly used herbs and plants that contain human MAO-B inhibitory properties in their natural form. This scientific research report lists natural herbs that work as MAO inhibitors thus these herbs work to reduce high Cortisol levels.

4. "CONCLUSION:These results indicate that daily supplementation with a combination of Magnolia bark extract and Phellodendron bark extract (Relora®) reduces cortisol exposure and perceived daily stress, while improving a variety of mood state parameters, including lower fatigue and higher vigor. These results suggest an effective natural approach to modulating the detrimental health effects of chronic stress in moderately stressed adults. Future studies should examine the possible performance and recovery benefits of Relora supplementation in athletes overstressed by the physical and psychological demands of training and competition." Relora is a trade name of NOW foods.

5. "These results confirmed the antidepressant-like effect of magnolol, which maybe primarily mediated by reversing the glial atrophy in the UCMS rat brain. (Atrophy means damage or killing of the glial cells in the brain, glial cells constitute the majority of brain cells. What this is saying is something doctors for ages claim can never happen, and that is the restoration of brain cells. Imagine what this could do for Parkisons, drug damage to the brain and Alzheimers.)

6. "The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the bark of Magnolia officinalis, and have been identified as major active components exhibiting anti-oxidative, anti-inflammatory, and neuroprotective effects. In this study, we investigate the ability of these isomers to suppress oxidative stress in neurons stimulated by the ionotropic glutamate receptor agonist N-methyl-D-aspartate (NMDA) and oxidative and inflammatory responses in microglial cells activated by interferon-? (IFN?) and lipopolysaccharide (LPS). We also attempt to elucidate the mechanism and signaling pathways involved in cytokine-induced production of reactive oxygen species (ROS) in microglial cells... RESULTS:Exposure of Hon and Mag (1-10 µM) to neurons for 24 h did not alter neuronal viability, but both compounds (10 µM) inhibited NMDA-stimulated superoxide production, a pathway known to involve NADPH oxidase. In microglial cells, Hon and Mag inhibited IFN?±LPS-induced iNOS expression, NO, and ROS production. Studies with inhibitors and immunocytochemical assay further demonstrated the important role of IFN? activating the NADPH oxidase through the p-ERK-dependent pathway. Hon and, to a lesser extent, Mag inhibited IFN?-induced p-ERK1/2 and its downstream pathway for ROS and NO production..." A report that agrees with report 5 that Magnolol reduces not only oxidative stress but depression and mental issues.

7. "...DHEA administration resulted in a decrease in plasma cortisol concentrations (mean, peak, and/or AUC) in healthy older women and men. The cortisol-lowering effect of DHEA was more pronounced in women than in men in our study..." This report states that DHEA lowers cortisol.



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