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Inhibin Date Written 3-3-10
Author Joe Holmes Date Revised  

Low Inhibin causes sterility in both sexes by causing low Follicle Stimulating Hormone (FSH). Thyroid releasing hormone (TRH) is related to the production of Inhibin.

1. "Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are called gonadotropins because stimulate the gonads - in males, the testes, and in females, the ovaries. They are not necessary for life, but are essential for reproduction. These two hormones are secreted from cells in the anterior pituitary called gonadotrophs. Most gonadotrophs secrete only LH or FSH, but some appear to secrete both hormones."

2. "Evidence for mutually antagonistic actions of thyroid releasing hormone and inhibin at pituitary-gonadal-prostate-spermatozoal axis. Sheth AR, Vanage GR, Bandivdekar AH.Institute for Research in Reproduction (ICMR), Parel, Bombay, India.

In-vivo as well as in-vitro studies carried out demonstrate for the first time the interaction between thyroid releasing hormone (TRH) and inhibin at the pituitary, testes, prostate and spermatozoa levels. At the pituitary level both peptides act as antagonists to each other and modify the release of pituitary hormones. Further, these peptides act at the prostatic level wherein they modulate ornithine decarboxylase activity as well as 5 alpha-reductase activity. At the testicular level TRH blocks inhibin biosynthesis whereas in semen, it significantly reduces the binding of spermatozoa to specific antibodies directed against inhibin. In conclusion, although TRH and inhibin are widely different in their molecular size and chemical structure, these peptides seems to act antagonistically at multiple sites. PMID: 3128722






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