Low Inhibin causes sterility in both sexes by causing
low Follicle Stimulating Hormone (FSH). Thyroid
releasing hormone (TRH) is related to the production
hormone (LH) and follicle-stimulating hormone (FSH)
are called gonadotropins because stimulate the gonads
- in males, the testes, and in females, the ovaries.
They are not necessary for life, but are essential
for reproduction. These two hormones are secreted
from cells in the anterior pituitary called gonadotrophs.
Most gonadotrophs secrete only LH or FSH, but some
appear to secrete both hormones." http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/lhfsh.html
"Evidence for mutually
antagonistic actions of thyroid releasing hormone
and inhibin at pituitary-gonadal-prostate-spermatozoal
axis. Sheth AR, Vanage GR, Bandivdekar AH.Institute
for Research in Reproduction (ICMR), Parel, Bombay,
In-vivo as well as in-vitro studies carried out
demonstrate for the first time the interaction between
thyroid releasing hormone (TRH) and inhibin at the
pituitary, testes, prostate and spermatozoa levels.
At the pituitary level both peptides act as antagonists
to each other and modify the release of pituitary
hormones. Further, these peptides act at the prostatic
level wherein they modulate ornithine decarboxylase
activity as well as 5 alpha-reductase activity.
At the testicular level TRH blocks inhibin biosynthesis
whereas in semen, it significantly reduces the binding
of spermatozoa to specific antibodies directed against
inhibin. In conclusion, although TRH and inhibin
are widely different in their molecular size and
chemical structure, these peptides seems to act
antagonistically at multiple sites. PMID: