Protien subfamily which is involved
in multi-drug resistance.
this mrp protien is involved in
drug resistance it may be a key
to understanding disease.
organic anion transporter 2 is
a protein that in humans is encoded
by the ABCC3 gene...It is a member
of the superfamily of ATP-binding
cassette (ABC) transporters. ABC
proteins transport various molecules
across extra- and intra-cellular
membranes. ABC genes are divided
into seven distinct subfamilies
(ABC1, ABC1, MRP, ALD, OABP, GCN20,
White). This protein is a member
of the MRP subfamily which is
involved in multi-drug resistance.
The specific function of this
protein has not yet been determined;
however, this protein may play
a role in the transport of biliary
and intestinal excretion of organic
anions. Alternatively spliced
variants which encode different
protein isoforms have been described;
however, not all variants have
been fully characterized."