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Vitamin B-12 deficiency, brain fog and depression

Low vitamin B-12 is linked to depression, cardiovascular (heart) disease, anemia, brain fog, thyroid and cognitive (brain) function.  May reverse cyanide poisoning. People over 50 are prone to B-12 deficiency. Report 5 shows a link to gastric issues that may impede B-12 absorption.

Vitamin C may impede B 12.

Vitamin B12 is also used for memory loss; Alzheimer’s disease; boosting mood, energy, concentration and the immune system; and slowing aging, heart disease, lowering high homocysteine levels (which may contribute to heart disease), male infertility, diabetes, sleep disorders, depression, mental disorders, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory bowel disease, asthma, allergies, a skin disease called vitiligo, preventing cervical and other cancers, and skin infections, amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, preventing the eye disease age-related macular degeneration (AMD), Lyme disease and gum disease, ringing in the ears, bleeding, liver and kidney disease, and for protection against the poisons and allergens in tobacco smoke.(see item 6)

1. Mayo Clinic article: "Recommended dietary allowances (RDAs) are 2.4 micrograms daily for adults and adolescents aged 14 years and older, 2.6 micrograms daily for adult and adolescent pregnant females, and 2.8 micrograms daily for adult and adolescent lactating females. Because 10-30% of older people do not absorb food-bound vitamin B12 efficiently, those over 50 years of age should meet the RDA by eating foods fortified with B12 or by taking a vitamin B12 supplement. Supplementation of 25-100 micrograms daily has been used to maintain vitamin B12 levels in older people. A doctor and pharmacist should be consulted for use in other indications.

For vitamin B12 deficiency, 125-2,000 micrograms of cyanocobalamin has been taken by mouth daily for up to 2.5 years or longer. Five hundred micrograms of sublingual (under the tongue) vitamin B12 has been used daily for up to four weeks. The following doses have been given intravenously (through the veins): 1,000 micrograms of intramuscular cobalamin once daily for 10 days (after 10 days, the dose was changed to once per week for four weeks, followed by once per month for life); 1,000 micrograms of intramuscular cyanocobalamin given on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 of treatment. For vitamin B12 deficiency caused by long-term PPI therapy, cyanocobalamin nasal spray has been used for eight weeks. The exact dosage is unclear. One clinical trial tested patients' acceptance of intranasal vitamin B12 replacement therapy (500 micrograms per week).

To lower homocysteine levels, 60-400 micrograms of vitamin B12 has been taken by mouth daily, as part of a B vitamin combination used for up to four years. ("homocysteine has been linked to cardiovascular disease")

For prevention of anemia, the following doses have been taken by mouth: 2-10 micrograms of vitamin B12 daily combined with iron and/or folic acid for up to 16 weeks; 100 micrograms of vitamin B12 every other week plus daily folic acid and/or iron for up to 12 weeks.

For cognitive function, the following doses have been taken by mouth: 10 micrograms or 50 micrograms of cyanocobalamin daily for one month; and one milligram of cyanocobalamin weekly for four weeks. One 1,000 microgram vitamin B12 injection has been used daily for five days, followed by one 1,000 microgram injection monthly for five months.

For acute cyanide poisoning, an intravenous infusion of five grams of hydroxocobalamin (up to 20 grams) has been used.

For depression, one milligram of cyanocobalamin, through intramuscular injections, was used weekly for four weeks.

For hereditary sideroblastic anemia, 100 micrograms of intramuscular vitamin B12 has been used monthly, with or without daily folic acid, for up to four months."  http://www.mayoclinic.com/health/vitamin-B12/NS_patient-vitaminb12/DSECTION=dosing

2. "CONCLUSIONS: Based on biochemical measures, elderly males are at higher risk of folate and vitamin B12 deficiencies. Ethnicity was not significantly related to either iron or folate status. Other Hispanics were significantly more likely to be vitamin B12 deficient." http://www.ncbi.nlm.nih.gov/pubmed/22364055

3. "Brain atrophy caused by vitamin B12-deficient anemia in an infant...Vitamin B12 deficiency in infants often presents with nonspecific hematological, gastrointestinal, and neurological manifestations. It is usually caused by inadequate intake, abnormal absorption, or congenital disorders of vitamin B12 metabolism, including transport disorders. We describe a vitamin B12-deficient infant with severe anemia who was breastfed. His mother had undiagnosed vitamin B12 deficiency having undergone total gastrectomy 18 years earlier. (Gastrectomies are performed to treat cancer and perforations of the stomach wal) The infant developed normally after taking vitamin B12. It is important to suspect vitamin B12 deficiency in mothers who have undergone gastrectomy. Early diagnosis and treatment of vitamin B12 deficiency in infants is important and will help improve long-term prognosis." http://www.ncbi.nlm.nih.gov/pubmed/21941150

4. "CONCLUSION: Because of the importance of vitamin B(12) in the development of the brain, MRI findings may be detected and useful in infants with vitamin B(12) deficiency." http://www.ncbi.nlm.nih.gov/pubmed/21903432

5. "A 36-year-old man was admitted to our hospital because of subacute progressive ataxic gait and dementia. His blood test results vitamin B12 deficiency due to presence of anti-intrinsic factor (stomach cell walls are not absorbing B-12) antibody and his endoscopic examination findings showed chronic gastritis. Treatment was administered on the bass of on a diagnosis of vitamin B12 deficiency. Consequently, ataxic gait improved and dementia regressed.¹²³I-IMP cerebral blood flow scintigraphy conducted at 8 months after treatment initiation showed increased blood flow the area around the parietal lobe to the corpus callosum, and flow both temporal lobes to the hippocampus compared. ..However, the disturbance in cerebral blood flow may be related to the dysfunction of higher brain function caused by vitamin B12 deficiency." http://www.ncbi.nlm.nih.gov/pubmed/21386128

6. "Vitamin B12 is used for treating and preventing vitamin B12 deficiency, a condition in which vitamin B12 levels in the blood are too low. It is also used to treat pernicious anemia, a serious type of anemia that is due to vitamin B12 deficiency and is found mostly in older people. For this purpose, people use either a supplement that is taken by mouth or a gel that is applied inside the nose.

Vitamin B12 is also used for memory loss; Alzheimer’s disease; boosting mood, energy, concentration and the immune system; and slowing aging. It is also used for heart disease, lowering high homocysteine levels (which may contribute to heart disease), male infertility, diabetes, sleep disorders, depression, mental disorders, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory bowel disease, asthma, allergies, a skin disease called vitiligo, preventing cervical and other cancers, and skin infections.

Some people use vitamin B12 for amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, preventing the eye disease age-related macular degeneration (AMD), Lyme disease and gum disease. It is also used for ringing in the ears, bleeding, liver and kidney disease, and for protection against the poisons and allergens in tobacco smoke.

Vitamin B12 is applied to the skin either alone or in combination with avocado oil for psoriasis and eczema.

Vitamin B12 is frequently used in combination with other B vitamins in various vitamin B complex products...vitamin C supplements can destroy dietary vitamin B12. "http://www.nlm.nih.gov/medlineplus/druginfo/natural/926.html

 

 

 

 
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