The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
 
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Brain Injury - Trauma

When we think of brain injury we are prone to think of trauma such as a concussion. There is a wave of new research that ties brain injury to oxidative stress. Much of the new research connects brain issues to a term called ischemia which is the scientific term meaning the constriction and restriction of blood vesels. Ischemia means the blood is not able to deliver nutrition and oxigen to the brain. In other research about the Sodium Potassium Pumps I wonder if electricity deliverance is also somehow reduced through nerves becomming restricted (ischemia)? I cannot provide science for this theory, but I will be evaluating it as I continue to study brain and oxidation reports.

I began this page after watching a news article about a man who developed depression and compulsive behaviors years after his High School football days, that some think came from head injuries. There is a growing concern in the medical industry for problems from head injuries especially those sustained in the sport of football. Their is a growing occurance of people suffering mood changes and Obsessive Compulsive Disorders many years after head injuries.

Anger management, anxiety, frustration, compulsive behaviors, brain fog, memory loss, brain function and depression are some of the effects of a brain injury. Unfortunately the general consensus is to ignore the possibility of a brain injury and diagnose its symptoms as depression or hypochondria. Usually the medical treatment is pharmaceutical drugs or counseling to treat the symptoms and may do nothing for the root causes.

Oxidative damage in the brain and its effect on a healthy brain may be one of the most important pieces of information about existing brain problems including depression. Oxidative damage to the brain may come from the general status of the body's oxidative stress and have nothing to do with a brain injury yet according to the research reports may cause brain problems.

Few in the medical community recognize that body organs, even the brain may be healed with natural compounds. If you do not believe brain cells can be healed study the research reports below. Alzheimer's, strokes, Autism, drugs, fevers, chemical imbalances, diseases effecting the brain, DNA, MS, memory loss, mental function, addictions and sex drive (up or down), hyper sex, compulsive behaviors may be caused by or may cause brain damage. The possibility exists that the herbs listed below may diminish if not heal their effects on the brain.

Oxidation is a new approach to mental health.

1. "A traditional Chinese herbal medicine, Qizhu Tang (QZT) was studied for its in vitro "test tube" antioxidant activity and the effect on cerebral oxidative damage after forebrain ischemia followed by reperfusion in rats. (ischemia is the constriction/restriction of blood vesels) ... Although some of the incomplete formulas showed as strong antioxidant activities as complete QZT in vitro, only the complete QZT formula was effective in preventing cerebral oxidative injury in rats, and other preparations showed limited activity in vivo. http://www.ncbi.nlm.nih.gov/pubmed/11379780?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
RVDocSum&ordinalpos=17

2. "QZT consists of 4 herbal constituents (Rhizoma Atractylodis Macrocephalae, Poria cocos, Kadix Notoginseng, and Radix Astragali), (Astragalus) of the components and their combinations were examined in vitro (test tube experiment) for 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical scavenging activities, and for the inhibition of thiobarbituric acid-reactive substances (TBARS) formation in rat liver homogenate. At the same time, their in vivo protective effect on cerebral ischemia-areperfusion injury was determined in rats... CONCLUSION: QZT formula is a good natural antioxidant having an effect." http://www.ncbi.nlm.nih.gov/pubmed/11603290

3. Shengmai San "...formulation for treating cardiac disorders, inhibited cerebral oxidative damage.."
http://www.ncbi.nlm.nih.gov/pubmed/14587874?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_
RVDocSum&ordinalpos=13

4. Ischemia-reperfusion injury's or simply the swelling, excess blood and damaged cells associated with a brain injury. These herbs may also help with strokes and aid the healing of existing as well as old brain injuries. Since they repair brain cells and improve brain nuerons and signal processing that means any brain problem may be helped.

5. Effects of Valproic Acid, a Histone Deacetylase Inhibitor, on improvement of Locomotor Function in Rat Spinal Cord Injury Based on Epigenetic Science...Background: The primary phase of traumatic spinal cord injury (SCI) starts by a complex local inflammatory reaction such as secretion of pro-inflammatory cytokines from microglia and injured cells that substantially contribute to exacerbating pathogenic events in secondary phase. Valproic acid (VPA) is a histone deacetylase inhibitor. Acetylation of histones is critical to cellular inflammatory and repair processes...The results showed a reduction in the development of secondary damage in rat spinal cord trauma with an improvement in the open field test (BBB scale) with rapid recovery. http://www.ncbi.nlm.nih.gov/pubmed/22801282   Valproic Acid is a pharmacutical derivitive from Valerian (herb) according to http://en.wikipedia.org/wiki/Valerian_%28herb%29

6. Herbs to treat brain injury
  • Paeonol  PMID: 16458462 , A definition of Paeonol
  • Beberine  PMID: 19457765 This report states it will also help treat strokes
  •  Sodium Ferulate PMID: 16237959   "Chukmesundan (CMSD) is composed of 8 medicinal herbs including Panex ginseng C.A. MEYER, Atractylodes macrocephala KOID, Poria cocos WOLF, Pinellia ternata BREIT, Brassica alba BOISS, Aconitum carmichaeli DEBX, Cynanchum atratum BGE, and Cuscuta chinensis LAM...that may be important for long-lasting neuronal responses."Sodium ferulate-PMID: 16176761   found in the root of Angelica sinensis. Definition of Sodium Ferulate
  • "...three Chinese herbs poria, rhizoma atractylodis macrocephalae, and radix angelicae sinensis..." PMID: 15740883
  • "Flavonoid wogonin...is neuroprotective by inhibiting inflammatory activation of microglia." PMID: 12897065  
    •  "Microglia are a type of glial cells that are the resident macrophages of the brain and spinal cord, and thus act as the first and main form of active immune defense in the central nervous system..."   source
  • Hwangryun-Hae-Dok-tang  "Our findings suggest that Scutellariae radix as an ingredient of HHDT plays a crucial protective role in ischemia-induced brain injury. In addition, it is apparent that the effect of Scutellariae radix is the result, in part, of baicalein, a compound contained in Scutellariae radix." PMID: 12204769
  • "The herbal preparation contained ginsengosides and extracts of Panax notoginseng, Ligusticum chuanxiong Hort., Carthamus tinctorius L. and Salvia militorrhiza Bge." PMID: 1791915


7. "Oxidative stress has been implicated in mechanisms leading to neuronal cell injury in various pathological states of the brain. Alzheimer's disease (AD) is a progressive disorder with cognitive and memory decline, speech loss, personality changes and synapse loss...Alzheimer's disease, in fact, involves a chronic inflammatory response associated with both brain injury and beta-amyloid associated pathology...These findings have offered new perspectives in medicine and pharmacology, as molecules inducing this defense mechanism appear to be possible candidates for novel cytoprotective strategies. In particular, manipulation of endogenous cellular defense mechanisms such as the heat shock response, through nutritional antioxidants or pharmacological compounds, represents an innovative approach to therapeutic intervention in diseases causing tissue damage, such as neurodegeneration. Consistent with this notion, maintenance or recovery of the activity of vitagenes, such as the HO gene, conceivably may delay the aging process and decrease the occurrence of age-related neurodegenerative diseases." http://www.ncbi.nlm.nih.gov/pubmed?term=repair%20brain%20injury%20herbs

 


 

 

 

 

 

 
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