The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
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Sleep Apnea

Item 2 brings up a big concern, that Sleep Apnea can effect Oxidation and even insulin sensitivity. In my study of hundreds of research reports Oxidation seems to be the fundamental equation in every disease, often called Metabolic Stress or Mayhem. These are either the result of factors like Sleep Apnea, external infections sources such as Malaria, or Diet. Whether the cause is from a disease or Oxidation causes a disease the harm to the body are the same.

Sleep disorder has been low in my evaluation and concern until I did this research. The reports below show information that has raised my concern and should raise the concern of anyone with sleep disorders. See the relationship to diabetes and insulin resistance in items 2 and 4. and glucocorticoids in reports 5 and 6 to infections within the body.

The most prevalent treatment by the medical industry is related to throat tissue collapse during sleep. The relationship to fungi is an emerging science not yet fully proven, yet enough to provide scientific documentation that it is a strong possibility to relate to sleep apnea. In collecting research one often can find reports proving as well as disproving a subject. There some of each relating to fungi and sinus infections causing sleep apnea. Since the prevalent medical industry's reluctance to accept yeast infections and fungi and the tremendous chatter via posts and the alternative health industry movement for this disease is so prevalent one may be unwise not to consider fungi in evaluating treatment for sleep apnea. (see the last three reports)

Note that three periods ... means content of a report is omitted for ease of reading and to avoid copyright infringement. Bold and underline text is by Herb-Discovery to draw attention to important items. Click the link to see the entire report.

1. "Does Home Sleep Testing Impair CPAP Adherence in Patients with Obstructive Sleep Apnea? Lettieri CF, Lettieri CJ, Carter K. 1Department of Family Medicine, DeWitt Army Community Hospital, Fort Belvoir, Virginia.
CONCLUSIONS: PAP usage did not differ between those undergoing HST versus in-lab studies. HST offers a more accessible and cost-effective alternative without compromising therapeutic adherence. PMID: 2129275

2. "Continuous Positive Airway Pressure Therapy Reduces Oxidative Stress Markers and Blood Pressure in Sleep Apnea-Hypopnea Syndrome Patients. Murri M, García-Delgado R, Alcázar-Ramírez J, Fernández de Rota L, Fernández-Ramos A, Cardona F, Tinahones FJ.Laboratorio de Investigaciones Biomédicas, Fundación IMABIS, Hospital Clínico Universitario Virgen de la Victoria, 29010, Málaga, Spain,

3. "Sleep apnea-hypopnea syndrome (SAHS) is characterized by recurrent episodes of hypoxia/reoxygenation, which seems to promote oxidative stress. SAHS patients experience increases in hypertension, obesity and insulin resistance (IR)... In conclusion, we observed an obvious improvement in oxidative stress and found that it was accompanied by an evident decrease in BP with no modification in IR. Consequently, we believe that the decrease in oxidative stress after 1 month of CPAP treatment in these patients is not contributing much to IR genesis, though it could be related to the hypertension etiology. PMID: 21286851

4. "Sleep duration and circulating adipokine levels. Hayes AL, Xu F, Babineau D, Patel SR. ... CONCLUSIONS: Reduced sleep and reduced REM sleep are associated with elevations in leptin and visfatin, 2 adipokines associated with inflammation and insulin resistance. Further investigation of the effect of sleep on adipose tissue function should be pursued... PMID: 21286230

5. "Macrophage Migratory Inhibitory Factor (MIF) May Be a Key Factor in Inflammation in Obstructive Sleep Apnea.Edwards KM, Tomfohr LM, Mills PJ, Bosch JA, Ancoli-Israel S, Loredo JS, Dimsdale J. ...CONCLUSION: MIF is elevated in patients with OSA and is related to OSA severity, while there was no difference in cortisol levels. MIF is a pro-inflammatory cytokine which additionally inhibits the anti-inflammatory effects of glucocorticoids. Thus, elevated MIF levels in OSA may contribute to elevated inflammation... PMID: 2128649

6. "Glucocorticoids (GC) are a class of steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. The name glucocorticoid (glucose + cortex + steroid) derives from their role in the regulation of the metabolism of glucose, their synthesis in the adrenal cortex, and their steroidal structure (see structure to the right). GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down. They are therefore used in medicine to treat diseases that are caused by an overactive immune system, such as allergies, asthma, autoimmune diseases and sepsis. GCs have many diverse (pleiotropic) effects, including potentially harmful side effects, and as a result are rarely sold over-the-counter.[1] They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. Wickipedia Definition

7. "New concepts in the management of chronic cough. Birring SS. King's College London, Division of Asthma, Allergy and Lung Biology, Denmark Hill, London SE5 9RS, United Kingdom. ...Obstructive sleep apnoea, tonsillar enlargement and environmental fungi have recently been described as causes of chronic cough... PMID: 21255671

8. "What Causes Sleep Apnea? When you're awake, throat muscles help keep your airway stiff and open so air can flow into your lungs. When you sleep, these muscles are more relaxed. Normally, the relaxed throat muscles don't prevent your airway from staying open to allow air into your lungs. National Heart & Lung Institute

9. Mayo Clinic; "...Obstructive sleep apnea occurs when the muscles in the back of your throat relax. These muscles support the soft palate, the triangular piece of tissue hanging from the soft palate (uvula), the tonsils and the tongue." Mayo Clinic

10. List of possible causes of Sleep Apnea
* Obesity
* Common cold
* Sinusitis
* Enlarged tonsils
* Enlarged adenoids
* Airway abnormality
* Nose abnormality
* Throat abnormality
* Chromosome 17, trisomy 17p11.2 - sleep apnea
* Mucopolysaccharidosis type I Hurler syndrome - sleep apnea
* Marfan syndrome - sleep apnea
* Glaucoma -- sleep apnea - sleep apnea
* Amyotrophic lateral sclerosis 3 - sleep apnea
* Adenoid disorders - sleep apnea
* Joubert Syndrome - sleep apnea
* Tonsilitis - sleep apnea
* Insomnia with sleep apnea - sleep apnea
* Arnold-Chiari malformation type 2 - sleep apnea
* Amyotrophic lateral sclerosis 6 - sleep apnea
* Charcot-Marie-Tooth disease, Type 1A - sleep apnea
* Amyotrophic lateral sclerosis 7 - sleep apnea
* Glycogenosis type 2 - sleep apnea
* Glycogen storage disease type 2 - sleep apnea
* Amyotrophic lateral sclerosis 8 - sleep apnea
* Adenoiditis - sleep apnea
* Pulmonary venous hypertension - breathing difficulty at night
* Metabolic Syndrome - sleep apnea
* Hypertrophyof tonsils and/or adenoids
* Chronic nasal obstruction, including choanal stenosis, severe septal deviation, allergic rhinitis, nasal polyps, and rare nasal and/or pharyngeal tumors
* Down syndrome
* Pierre Robin anomaly
* Crouzon syndrome
* Treacher Collins syndrome
* Klippel-Feil syndrome
* Beckwith-Wiedemann syndrome
* Apert syndrome
* Prader Willi syndrome
* Morbid obesity
* Achondroplasia
* Laryngomalacia
* Mucopolysaccharidoses

11. "Some of the tell-tale symptoms of Obstructive Sleep Apnea:

* mood changes, depression, irritability
* sudden waking from sleep, short of breath
* waking with a dry mouth or sore throat
* morning headaches
* chronic loud snoring (the inability to stop snoring is often the first thing noticed by others who sleep near you)
* memory problems

OSA is more common in men than women, and risk increases with age. Other risk factors can include:

* extra fat around the airway
* high blood pressure
* neck size
* use of sedatives or alcohol
* cigarette smoking
* a naturally-occuring narrowed airway (due to heredity or enlarged tonsils)

12. This is one site that sells a dental device to replace the CRAP machine "The FDA has approved American Sleep Association's oral appliance for reducing and eliminating sleep apnea and snoring. The Department of Health reports that 80% of current CPAP users prefer an oral appliance over their CPAP to reduce sleep apnea."
I verified these research reports exist from their site PMID: 7097922 , PMID: 4004636

13. "...And dental devices — they resemble athletic mouth guards — can open up the back of the throat by moving the lower jaw and tongue forward..." Harvord Medical School

14. "Prevalence of extramucosal fungal elements in sinonasal polyposis: a mycological and pathologic study in an Egyptian population. Bassiouny A, Ragab A, Attia AF, Atef A, Hafez N, Ayad E, Sameer H. Faculty of Medicine, Department of Otolaryngology, Cairo University, Cairo, Egypt. "RESULTS AND CONCLUSION: The postulated criteria for the diagnosis of allergic fungal sinusitis were present in 92% of CRS with polyposis, suggesting that fungi are involved in the disease process of most CRS patients." PMID: 20832908   Herb-Discovery comment; CRS stands for chronic rhinosinusitis found in sinus infections. This report sugests that up to 92% of sinus and possibly sleep problems may be the result of fungus. Since most in the medical community are ignoring fungus and especially related to sleep and sinus problems this is an important research report. There is no question physical problems such as inflexable throute tissues during sleep can cause sleep apnea, however this important tidbit of science is not being considered. Since it is in the medical industries intrest to make money the simple cures like treating fungus is not being taught to our doctors.

15. "Allergic fungal rhinitis and rhinosinusitis. Hamilos DL. Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, 55 Fruit Street, Bulfinch-422, Boston, MA 02114, USA. ... owing to the demonstration of fungi in mucus in the vast majority of cases of CRS, ... PMID: 20463255

16. "Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis. Tieu DD, Kern RC, Schleimer RP.Department of Otolaryngology-Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. ...Chronic rhinosinusitis (CRS) is characterized by a chronic symptomatic inflammation of the nasal and paranasal sinus mucosae and is one of the most frequently reported chronic diseases in the United States, with an estimated prevalence of greater than 10% of the general population. PMID: 19560577

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