The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
 
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Garlic Date Written 2007
Author Joe Holmes Date Revised  

In the attached scientific reports 1-4 you will find proof that garlic is a strong antibiotic.

Our comments are in italics and brown color. PMID research reports are written to be read by pharmaceutical companies and may be written specifically to not be understood by lay persons. Rats are one animal that mimics the human body and if the study uses rats, pharmaceutical companies know it will work on humans.

1. "Berginc K, Zakelj S, Ursic D, Kristl A. Faculty of Pharmacy, University of Ljubljana. The growing concomitant consumption of drugs and herbal preparations such as garlic, and the numerous reports about the influence of herbal preparations on intestinal transport, led us to evaluate the influence of aged garlic extract on the transport function and electrophysiological parameters of the small intestinal mucosa. Aged garlic extract induced increase of the absolute value of the transepithelial potential difference and of the short-circuit current in both permeability models tested (rat jejunum, Caco-2 cell monolayers) without affecting transepithelial electrical resistance. It also caused a significant increase of the P-glycoprotein and multidrug resistance associated protein 2 mediated effluxes through rat jejunum of marker substrates Rhodamine 123 and 2,4-dinitrophenyl-S-glutathione, respectively. Rhodamine 123 efflux through the Caco-2 cell monolayers was not altered by aged garlic extract, whereas the efflux of 2,4-dinitrophenyl-S-glutathione increased significantly. So altered activity of the important transport proteins could significantly change the pharmacokinetic properties of conventional medicines taken concomitantly with aged garlic extract.PMID: 19336907 Often people mistakenly think tests on rats are not equivalant to humans. Pharmicutical companies know if a compound test favorably on rats it will work on humans. (1)

2. "Hassan HA, El-Agmy SM, Gaur RL, Fernando A, Raj MH, Ouhtit A. Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt. Sodium nitrite (NaNO2), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO2-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO2 treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a pharmacokinetic with powerful chemopreventive properties against chemically-induced oxidative stress. PMID: 19305642 Garlic has potential to improve oxidative stress which is the fundimental aspect to good health. In this report it can even counter the cancer danger of a toxic food additive. (2)

3. "An M, Shen H, Cao Y, Zhang J, Cai Y, Wang R, Jiang Y. Department of Clinical Pharmacology, Chinese People's Liberation Army General Hospital, Beijing, PR China. maoan168@yahoo.com.cn
Amphotericin B (AmB) is the gold standard of antifungal treatment for the most severe invasive mycoses. In addition to the interaction of AmB with ergosterol in the fungi cell membrane, several studies have demonstrated oxidative damage involved in the fungicidal activity of AmB. In this study, allicin, an allyl sulphur compound from garlic, was shown to enhance significantly the effect of AmB against Candida albicansAn M, Shen H, Cao Y, Zhang J, Cai Y, Wang R, Jiang Y. Department of Clinical Pharmacology, Chinese People's Liberation Army General Hospital, Beijing, PR China. maoan168@yahoo.com.cn Amphotericin B (AmB) is the gold standard of antifungal treatment for the most severe invasive mycoses. In addition to the interaction of AmB with ergosterol in the fungi cell membrane, several studies have demonstrated oxidative damage involved in the fungicidal activity of AmB. In this study, allicin, an allyl sulphur compound from garlic, was shown to enhance significantly the effect of AmB against Candida albicans in vitro (in a test tube or petri dish) and in vivo, (in a living organism) although allicin did not exert a fungicidal effect. Further study first demonstrated that allicin-mediated oxidative damage, such as phospholipid peroxidation in the plasma membrane, via influencing the defence of C. albicans against oxidative damage may be the cause of the synergistic interaction between allicin and AmB. We envision that a combination of AmB with allicin may prove to be a promising strategy for the therapy of disseminated candidiasis.PMID: 19095412 Garlic has ability to aid and heal oxidative stress which in turn aids the immune system. Garlic works similar to an antibiotic but without harming oxidative stress like antibiotics do. (3)

4. Cutler RR, Odent M, Hajj-Ahmad H, Maharjan S, Bennett NJ, Josling PD, Ball V, Hatton P, Dall'Antonia M. University of East London, Romford Rd, Stratford, London E15 4LZ, UK. rcutler@uel.ac.uk
BACKGROUND: Studies have shown the efficacy of intra-partum (birth and delivery) antibiotics in preventing early-onset group B streptococcal sepsis. This approach results in a high intra-partum antibiotic use. Worryingly, the same antibiotics used in prophylaxis (antibiotics to fight disease) are also first-line treatment for neonatal sepsis, (infections in newborn) and antibiotic exposure in the peri-natal period has been shown to be a risk factor for late-onset serious bacterial infections and allergic disease. Antibiotic exposure in the peri-natal period is becoming a major public health issue; alternative strategies are needed. Garlic has been traditionally used to treat vaginal infections. Allicin is the main antibacterial agent isolated from garlic. OBJECTIVES: The aim of the study was to investigate the in vitro activity of a novel allicin (garlic) extract in aqueous and gel formulation against 76 clinical isolates of Lancefield group B streptococci (GBS). METHODS: MICs and MBCs of allicin were determined for 76 GBS isolates by agar dilution and microtitre plate methods. Killing kinetics were determined for a selected 16 of the 76 strains. Agar diffusion tests were compared for allicin liquid and gel (500 mg/L). RESULTS AND CONCLUSIONS: MICs and MBCs of allicin liquid were 35 to 95 mg/L and 75 to 315 mg/L, respectively. Time/dose kill curves produced a 2-3 log reduction in cfu/mL within 3 h and no detectable growth at 8 and 24 h. A novel 500 mg/L allicin gel produced an average zone size of 23+/-6 mm compared with 21+/-6 mm for allicin in water. Aqueous allicin is bactericidal against GBS isolates and maintains activity in a novel gel formulation. PMID: 19001449 In simpler words garlic kills 16-76 strains of infections, thus it is saying garlic is a strong antibiotic. (4)

5. "Garlic Increases Antioxidant Levels in Diabetic and Hypertensive Rats Determined by a Modified Peroxidase Method.
Drobiova H, Thomson M, Al-Qattan K, Peltonen-Shalaby R, Al-Amin Z, Ali M.
Department of Biological Sciences, Faculty of Science, Kuwait University, P.O. Box 5969, 13060-Safat, Kuwait. mmtkuwait2003@hotmail.com.

Oxidative damage by free radicals has been implicated in the pathogenesis of vascular disease in diabetes and hypertension. In the present study, the total antioxidant status in diabetic and hypertensive rats before and after treatment with garlic (Allium sativum) was determined. The total serum antioxidants were measured by a modified method reported earlier by Miller and coworkers. The reproducibility of the assay was confirmed by determining standard curves for the known antioxidants: trolox (a stable analog of vitamin E), glutathione and vitamin C with interassay correlation coefficients (R(2), n = 10 in triplicate) of 0.9984, 0.9768 and 0.987, respectively, confirming the reliability and reproducibility of the assay. This assay was then used to determine total serum antioxidant levels of streptozotocin-induced diabetic rats and two-kidney one-clip hypertensive rats both before and after 3 weeks of treatment with an aqueous extract of garlic (500 mg/kg IP daily). The serum antioxidant levels of rats after 3 weeks of treatment were significantly higher (P < 0.001) than the pretreatment levels in both diabetic and hypertensive rats. The increased serum antioxidant levels were paralleled by a decrease in serum glucose in the garlic-treated diabetic rats and lowered systolic blood pressure in the garlic-treated hypertensive rats. We conclude from our study that (i) total antioxidants can be measured by a simple, reproducible, reliable assay and (ii) the total antioxidant status can be significantly improved by treatment with garlic." PMID: 19233877

I will stop with just enough scientific reports to prove a point. If you want to see more proof and research go to http://www.ncbi.nlm.nih.gov/pubmed/  Type in "garlic antibiotic" in the search window.

1 PMID 19336907
2 PMID: 19305642
3 PMID: 19095412
4 PMID: 19001449
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