The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
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Geranium (Bis beta-carboxyethyl germanium sesquioxide) Date Written  
Author Joe Holmes Date Revised  

Known as Ge 132
This is absolutely amazing research everyone needs to know. As I collect research the damage of oxidatants and the benifits of anti-oxidants is amazing. Few recognize oxidative stress as the main center of disease. My collections of research indicate oxidative stress can cause many diseases, while those that are not caused by it actually cause oxidative stress. In other words research indicates oxidative stress seems to be the commonality in all diseases. The most reported means to combat oxidative stress has been to lower oxidants and increase anti-oxidants. Some suggest a ratio of 30% oxidants to 70% anti-oxidants are required to restore and maintain health. The reports below show that Ge 132 provides another way to fight oxidative stress. Remember oxidants are unbalanced electrons and anti-oxidants are balanced electrons. Ge132 is reported to balance the electrons thus destroying oxidation. it is also reported to do this within the cells not outside the cells. This is amazing important information. Read our pages on Oxidative Stress and Antioxidants

See our page on how to read and understand research reports Click

1. "Before you go out and purchase Germanium per se, keep in mind that it is a very toxic and poisonous substance in its natural form, or in the form of many of its salts. It's not "Germanium" that you are after, but rather a new substance called bis beta-
carboxyethyl germanium sesquioxide
, since also titled as Ge 132 (mu-trioxo-bis [beta-carboxyethyl] germanic anhydride). Its inven-
tor and developer, Kazukiko Asai, a Japanese chemist and coal engineer, tested 132 compounds of Germanium, finally ending
with this one -- thus titled Ge 132. For those of you who know about and use herbs, it is of interest to note that organic germanium is an active ingredient in garlic, aloe, comfrey, chlorella, ginseng, watercress, shelf fungus (which is a variety of Reishi mushroom), Shiitake mushrooms, pearl barley, sanzukon, sushi, waternut, boxthorn seed and wisteria knob. It will also interest you to learn that many of the traditional problems for which the above specific natural substances are recom- mended, are also solved when using organic Ge...
A most interesting charac- teristic of Germanium is its ability to relieve a great deal of pain. It does this by inhibiting the natural body enzyme that, in turn, inhibits production of the body’s endorphins. Endorphins are substances produced in the brain that naturally raise the pain threshold. Some of us produce more endorphins than others, and those that produce very little are highly sensitive to pain. Another way of describing the phenomenon of pain sensitivity is in the recognition that some of us produce more of the enzyme that blocks the utilization of our own endorphins, thus making us more sensitive to pain. Bis beta-carboxyethyl germanium sesquioxide inhibits the endorphin inhbitor...The effects of Ge 132 on various immune parameters are almost identical to that of known gamma interferon immunomodulating activity. In addition, studies on immune-suppressed animals and on patients with malignancies or rheumatoid arthritis suggest that Ge 132 normalized the function of T cells, B lymphocytes, anti-body-dependent cellular cytotox- icity, natural killer cell activity and numbers of antibody-forming cells. Obviously organic germanium has a “normalizing” influence on the immune system. A key characteristic of Germanium is its ability to “normalize” many physiological functions. For example, it has the ability to lower blood pressure on hypertensive people. This normalizing effect may extend to a broad variety of physiological/ biochemical functions, such as restoration of deviant blood parameters to their normal ranges, including pH, potassium, calcium, chloride, triglycerides, cholesterol, bilirubin, uric acid, and blood hemoglobin...In a sense, like EDTA Chelation therapy, which scavanges free-radicals throughout the circulatory system outside the cell, Ge 132 scavanges electrons before they will produce free-radicals (oxidatants) inside the cell. Bis beta-carboxyethyl germanium sesquioxide is virtually non-toxic to the human system..." Go to this source to read the entire article.

2."Bioinorg Chem Appl. 2009:908625. Epub 2009 Jun 2. Synthesis and evaluation of novel organogermanium sesquioxides as antitumor agents. Zhang CL, Li TH, Niu SH, Wang RF, Fu ZL, Guo FQ, Yang M. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100083, China. Five new organogermanium sesquioxides have been synthesized and characterized by elemental analysis and IR spectra. All the compounds were tested for antitumor activities against KB, HCT, and Bel cells in vitro. Compound 5 (gamma-thiocarbamido propyl germanium sesquioxide) showed excellent antitumor activity,... The tumor clearance was slow. The results showed that compound 5 may be developed to be a suitable cancer therapeutic agent." PMID: 19753138

3."[Studies on the hydroxyl free radical-scavenging effect of combined selenium and germanium] [Article in Chinese] Wu Z, Chen X, Yang K, Xia T. Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

The effect of selenium, carboxyethyl-germanium sesquioxide (Ge-132) and the combination of selenium and Ge-132 on the production of hydroxyl free radical in liver microsomes of rats treated with Fe2SO4-NADPH system was studied with electron spin resonance technique (ESR). The results showed that the production of hydroxyl free radical was decreased significantly by adding selenium, Ge-132 and combined selenium and Ge-132, indicating a direct scavenging effect on hydroxyl free radical. It was also observed a enhanced scavenging effect at the low concentration of combined selenium and Ge-132." PMID: 12561515 See the two items below for definitions to better understand that this scientific research report is showing Ge 132 with selenium removes oxidation. See our page on selenium that shows one should use the vegtable not the mineral version of selenium.

  1. "The hydroxyl radical, ·OH, is the neutral form of the hydroxide ion. Hydroxyl radicals are highly reactive and, as a consequence, short-lived; however, they form an important part of radical chemistry. Hydroxyl free radicals cause damage to oxidative cells, particularly erythrocytes (or red blood cells)." Wikipedia
  2. Scavenging effect means to remove harmful oxidants. "1. to search for (anything usable) among discarded material
    2. (Engineering / Metallurgy) (tr) to purify (a molten metal) by bubbling a suitable gas through it. The gas may be inert or may react with the impurities 3. to clean up filth from (streets, etc.) 4. (Chemistry) Chem to act as a scavenger for (atoms, molecules, ions, radicals, etc.)

4."[An observation of antiproliferative effect of germanium-132 on cultured pterygium fibroblasts] [Article in Chinese] Liu Y, Sun X, Li B, Wang J. Beijing Institute of Ophthalmology, Beijing 100005, China.

OBJECTIVE: To detect the antiproliferation of carboxyethyl germanium sesquioxide (Ge-132) on fibroblasts of pterygium in vitro and try to find a potentially effective agent for treatment of primary pterygium and prevention of its postoperative recurrence. METHODS: Primary culture and subculture of pterygium fibroblasts were established in vitro. Different concentrations of Ge-132 (39 - 5,000 mg/L) or mitomycin-C (3.13 - 4.00 mg/L, the control) were added to the fibroblast culture of the third or forth passage respectively. The inhibitory effect was determined by MTT (tetrazolium bromide) method. The influence of addition of Ge-132 on the growth curve of fibroblasts was observed, and the changing expression of proliferating cell nuclear antigen (PCNA) in fibroblasts was studied by immunohistochemical method. RESULTS: The addition of Ge-132 in the culture caused significant inhibition of the fibroblast proliferation in dose dependent manner (625 - 50,000 mg/L) without cytotoxicity (IC(50) = 3,000 mg/L), the marked descent of growth curve and suppression of the expression of PCNA in cultured cells (P < 0.01). CONCLUSION: Ge-132 can inhibit the proliferation of pterygium fibroblast in vitro significantly. PMID: 11853609 (It stops damaging growths)

  1. Fibroblasts: A fibroblast is the most common type of cell found in connective tissue. Fibroblasts secrete collagen proteins that are used to maintain a structural framework for many tissues. They also play an important role in healing wounds."
  2. Pterygium: a triangular fleshy mass of thickened conjunctiva occurring usually at the inner side of the eyeball, covering part of the cornea, and causing a disturbance of vision 2 : a forward growth of the cuticle over the nail
  3. In Vetro: outside the living body and in an artificial environment <growth of cells in vitro> <in vitro studies> (such as in a test tube or petri dish)

4."Effect of germanium-132 on low-density lipoprotein oxidation and atherosclerosis in Kurosawa and Kusanagi hypercholesterolemic rabbits.Wakabayashi Y.Department of Medicine, University of Kitasato Medical School, Sagamihara, Japan.

Germanium-132 (Ge-132) was given at 200 mg/kg of body weight to 8-week-old Kurosawa and Kusanagi hypercholesterolemic (KHC) rabbits. Thirty-six weeks later, the susceptibility of plasma low-density lipoprotein to oxidation and the morphology of atherosclerosis in the aorta and coronary artery were investigated. Treatment with Ge-132 resulted in decreases in the oxidation rate and in the formation rate of thiobarbituric acid-reactive substances following copper-induced oxidation of LDL. Ge-132 is suggested to possess antioxidative properties, but this did not lead to any attenuation of atherosclerotic progression in the KHC rabbits." PMID: 11577738


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