The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
 
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Ginseng - Panax American ginseng is reported to be as potent as Korean or Asian varieties. a genus of 11 species Wickipedia

Traditional history: effects of stress, improve performance, boost energy levels, enhance memory, stimulate the immune system, remove both mental and bodily fatigue, treat pulmonary problems, dissolve tumors and reduce

the effects of age, contains vitamins A, B-6 and the mineral Zinc, act on the adrenal glands, helping to prevent adrenal hypertrophy and excess corticosteroid production in response to physical, chemical or biological stress, increase protein synthesis and activity of neurotransmitters in the brain, restore memory, and enhance concentration and cognitive abilities, helps blood supply to the brain, increase energy, resist viral infections and environmental toxins. support the central nervous system, liver function, lung function, circulatory system, increase natural killer cell activity, lower cholesterol and decrease triglyceride levels, improve male sexual function and remedy impotence, increase estrogen levels in women and treat menopausal symptoms, diabetes, radiation and chemotherapy protection, colds, chest problems, aid in sleep, and stimulate the appetite.

Ginseng has tremendous properties and in several of the research reports its ability to supress Kappa B is one of its best effects for helping the body. Study Kappa B to see why this is so important.

1. Ginseng: Ginseng may cause headache, tremulousness, and manic episodes in patients treated with phenelzine sulfate. Ginseng should also not be used with estrogens or corticosteroids because of possible additive effects. http://floraleads.com/herbs4health.htm

2. "Siberian ginseng has been shown to be especially helpful for people experiencing stress or stressful situations because it inhibits the alarm phase (fight or flight response) of the stress reaction.1 The Chinese take it as a remedy for insomnia and believe that regular use will increase longevity, improve general health and appetite, and restore memory. In traditional Chinese medicine, it is used to reinforce “Qi” and invigorate the function of spleen and kidney. The Russians were the first to use Siberian Ginseng as a training aid for their athletes with dramatic results. The Russian Olympic team has publicly acknowledged its use since 1972 and credits its effects for the capture of eleven gold medals at the Lillehammer Winter Olympics in 1994. It has been used (and still is) by the Russians to increase performance, bolster the immune system, reduce fatigue after workouts, and lower the effects of stress — all with no side effects. Over-trained athletes often have high levels of stress-induced cortisol, a catabolic (protein-destroying) stress hormone. Siberian ginseng deactivates cortisol before the hormone can cause tissue damage.2 Siberian ginseng even supports the body during traditional cancer treatments by helping the liver detoxify harmful toxins including those from chemotherapy and radiation exposure.3 Research has also shown that it has a pronounced effect on the immune system. It improves the function of T cells (mostly T-helper cells), cytotoxic and natural killer (NK) cells, and increases the production of virus-fighting interferon." http://www.totalhealthbreakthroughs.com/2008/10/the-herb-emporium-siberian-ginseng/

3. Korean Red Ginseng (KRG) "Tissues from the non-KRG-treated pancreatitis group exhibited marked pancreatic damage including changes in histological architecture, acinar cell necrosis and degeneration, and cytoplasmic vacuolization. However, tissues from the KRG-treated pancreatitis group exhibited no cellular damage and had normal histological pancreatic architecture. Immunohistochemical examination revealed that the expressions of nuclear factor kappaB, tumor necrosis factor alpha, inducible nitric oxide synthase, and the oxidant stress markers, malondialdehyde and 4-hydroxynonenal, were significantly decreased in the KRG-treated pancreatitis group as compared with the non-KRG-treated pancreatitis group. CONCLUSIONS:: Our results suggest that KRG has antioxidant therapeutic effects on superoxide dismutase inhibitor-induced pancreatitis by inhibition of nuclear factor kappaB." http://www.ncbi.nlm.nih.gov/pubmed/?term=PMID%3A+19531970 Web master note: The main cause of infections and any disease is kappaB thus this statement is telling us that KRG will fight kappaB. Most drs. unknowingly call kappaB and oxidation metabolic failure where the whole body self destructs. Many nutritionist also do not understand kappaB, but understand very well the importance of antioxidants which all fight kappaB. .

4. Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries. (Kidney injuries)
Liver, being primary site for biotransformation of foreign compounds is vulnerable to various chemical assaults. Ginseng has a wide range of pharmacological and therapeutical action. In the present study an attempt has been made to study the cadmium chloride (CdCl(2)) induced toxicity in liver and its possible protection by Panax ginseng. Swiss albino mice were divided into four groups: (i) Control group--only vehicle (double distilled water) (ii) Ginseng treated group - 10mg/kg b.wt. orally (iii) CdCl(2) treated group - 1.0mg/kg b.wt. CdCl(2) i.p. (iv) Combination group--Ginseng root extract (10mg/kg b.wt.) and CdCl(2) (1.0mg/kg b.wt.). Activities of alkaline phosphatase, GOT, GPT were measured in serum and lipid peroxidation (LPO) and GSH content were measured in liver. The results indicated a significant increase in LPO, GOT, GPT activities and decrease in GSH and serum alkaline phosphatase activities after CdCl(2) treatment. Ginseng alone did not show any significant alterations except a significant decrease in LPO level. Combined treatment of Ginseng and CdCl(2) showed significant decrease in LPO, GOT, GPT and elevation in GSH and serum alkaline phosphatase as compared to CdCl(2) treated group. Thus, Ginseng is found to be protective against cadmium-induced hepatic injuries." (Kidney injuries) http://www.ncbi.nlm.nih.gov/pubmed/?term=19168115

5. Flower extract of Panax notoginseng attenuates lipopolysaccharide-induced inflammatory response via blocking of NF-kappaB signaling pathway in murine macrophages. Jung HW, Seo UK, Kim JH, Leem KH, Park YK. Department of Herbology, College of Oriental Medicine, Dongguk University, Gyeongju 780-714, South Korea.

AIM OF THE STUDY: The root of Panax notoginseng (PN) is commonly used to treat chronic liver disease with its therapeutic abilities to stop haemorrhage in the circulation, while the PN flower (PN-F) is largely unknown in the biological activities on inflammation and mechanisms of its actions. In this study, the pharmacologic effects of PN-F methanol extract on inflammation were investigated to address potential therapeutic or toxic effects in LPS-stimulated mouse macrophage cells, RAW264.7 cells. MATERIALS AND METHODS: Production of NO, PGE2 and pro-inflammatory cytokines (TNF-alpha and IL-1beta) in supernatant, the expression of iNOS, COX-2 and cytokines, the phosphorylation of MAPK molecules (ERK1/2, JNK and p38 MAPK), and the activation of NF-kappaB in PN-F extract were assayed in LPS-stimulated RAW264.7 cells. RESULTS: PN-F extract significantly inhibited the productions of NO, PGE2, TNF-alpha and IL-1beta on the LPS-stimulated RAW264.7 cells. In addition, PN-F extract suppressed the mRNA and protein expressions of iNOS, COX-2, TNF-alpha and IL-1beta in LPS-stimulated RAW264.7 cells. The molecular mechanism of PN-F extract-mediated attenuation in RAW264.7 cells has close a relationship to suppressing the phosphorylation of MAPK molecules such as ERK1/2, JNK and p38 MAPK, and the translocation of NF-kappaB p65 subunit into nuclear. CONCLUSION: These results indicate that PN-F extract inhibits LPS-induced inflammatory response via the blocking of NF-kappaB signaling pathway in macrophages, and demonstrated that PN-F extract possesses anti-inflammatory properties in vitro." http://www.ncbi.nlm.nih.gov/pubmed/?term=19162159

6. "Korean red ginseng extract (RGE) is one of the most popular natural herbs modulating the immune system. Although the effects of RGE on immunity have been reported, its effects on inflammasomes, multi-protein complexes that activate caspase-1 to induce maturation of interleukin (IL)-1ß, have not been studied yet. In this study, we elucidated the effect of RGE on inflammasome activation using mouse and human macrophages. In our results, RGE inhibited IL-1ß maturation resulting from NLRP3 inflammasome activation in both in vitro and in vivo models. In addition, RGE strongly attenuated IL-1ß secretion as well as pathogen clearance via pyroptotic cell death by macrophages through inhibition of AIM2 inflammasome activation. Ginsenosides Rg1 and Rh3 were suggested as inhibitors of the inflammasome activation. Thus, we demonstrated that RGE inhibits both NLRP3 and AIM2 inflammasome activation, with predominant involvement of the AIM2 inflammasome." http://www.ncbi.nlm.nih.gov/pubmed/24418475 (KRG aids the immune system)

 

 
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