The purpose of this site is to collect lab research by medical doctors about herbs that are proven to treat illnesses and counter the false attacks on herbs by the medical industry and false claims by alternative medicine. I let the science tell the facts.
 
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Oats Oat Straw Date Written 6-21-09
Author Joe Holmes Date Revised  

Oats are reported to improve liver function, lower cholesterol in the whole body and the liver, and help sexual function

1. "Oatstraw is a wonderful nourishing herb that is one of the better natural remedies known for treatment of stress, emotional challenges, fatigue, and exhaustion, and is also used to treat impotence. It is excellent for rejuvenation of the nervous system, especially after long-term burn out. As such, it is also used to improve brain function and the nervous system stress. It is very useful for aiding your body in correcting sexual debility. Overall oastraw play a vital role in your sexual health.." (1)


2. Oats do not interfere with Celiac Disease "Paediatric Research Centre, University of Tampere, Tampere, Finland. OBJECTIVES: A gluten-free diet omitting wheat, rye, and barley is the only effective treatment for coeliac disease. The necessity of excluding oats from the diet has remained controversial....CONCLUSIONS: Consumption of oats does not induce TG2 autoantibody production at mucosal level in children with coeliac disease. Measurement of small-intestinal mucosal autoantibody deposits is suitable for monitoring treatment in coeliac patients." PMID: 19412007 (2)

2. Human Nutrition Research Center on Aging "...These data suggest that the avenanthramides in oats may have great potential to prevent vascular dysfunction and development of atherosclerotic lesion by inhibiting vascular SMC proliferation and increasing NO production. Supported by USDA agreement No.58-1950-9-001. (1)

3. The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes. Liatis S, Tsapogas P, Chala E, Dimosthenopoulos C, Kyriakopoulos K, Kapantais E, Katsilambros N. First department of internal medicine, Athens university medical school and diabetes center, Laiko hospital, 11527 Athens, Greece. s.liatis@yahoo.com

AIM: Previous studies have shown that the water-soluble dietary fibre betaglucan, a natural component of oats, reduces cholesterol and postprandial hyperglycaemia. The aim of the present study was to investigate the effect of betaglucan-enriched bread consumption on the lipid profile and glucose homoeostasis of patients with type 2 diabetes (T2D). METHODS: We conducted a randomized, double-blind study in which 46 patients with T2D and LDL-C greater than 3.37 mmol/l (130 mg/dl) were randomized to incorporate into their diet, for 3 weeks, either bread enriched with betaglucan (providing 3g/day of betaglucan) or white bread without betaglucan. RESULTS: The consumption of bread containing betaglucan led to significant reductions (vs the control group) in LDL-C of 0.66 mmol/l (15.79%) versus 0.11 mmol/l (2.71%) (P=0.009), in total cholesterol of 0.80 mmol/l (12.80%) versus 0.12 mmol/l (1.88%) (P=0.006), in Fasting plasma insulin (FPI) of 3.23 microU/ml versus an increase of 3.77 microU/ml (P=0.03) and in Homa-IR (Homoeostasis model assessment-insulin resistance) by 2.08 versus an increase of 1.33 (P=0.04). CONCLUSIONS: Betaglucan enriched bread may contribute to the improvement of the lipid profile and insulin resistance in patients with T2D. PMID: 19230737(3)

4. Oat: unique among the cereals. Sadiq Butt M, Tahir-Nadeem M, Khan MK, Shabir R, Butt MS. Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.

This review is intended to focus on the composition of oat and its therapeutic potential in the pharmacology that supports its use to cure various maladies. Oat (Avena sativa) is distinct among the cereals due to its multifunctional characteristics and nutritional profile. Recent advancement in food and nutrition has revealed the importance of its various components. It is a good source of dietary fiber especially beta-glucan, minerals and other nutrients. Oat and oat by products have been proven to be helpful in the treatment of diabetes and cardiovascular disorders. Oat bran in particular, is good source of B complex vitamins, protein, fat, minerals besides heart healthy soluble fiber beta-glucan. The beta-glucan has outstanding functional properties and is of immense importance in human nutrition. Different physiological effects of beta-glucan are related to its viscosity, attenuation of postprandial plasma glucose and insulin responses, high transport of bile acids towards lower parts of the intestinal tract and high excretion of bile acids thereby lowering of serum cholesterol levels. Moreover, it is helpful against coeliac disease. The incorporation of oat grains and oat bran in the food products improves not only the nutrition but also a therapy against various maladies." PMID: 18301937 (4)

5. Oat bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study. Ellegård L, Andersson H. Department of Clinical Nutrition, The Sahlgrenska Academy at the University of Göteborg, Sahlgrenska University Hospital, SE-405 30 Göteborg, Sweden. Lasse.Ellegard@nutrition.gu.se

OBJECTIVE: To study whether oat bran with native beta-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HC). DESIGN: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. SETTING: Outpatients at a metabolic-ward kitchen. SUBJECTS: Nine volunteers with conventional ileostomies. METHODS: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded oat bran breakfast cereal daily, with either 11.6 g native or hydrolysed beta-glucans. RESULTS: Native oat bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed oat bran. 7alpha-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015). CONCLUSIONS: Oat bran with native beta-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7alpha-HC. Thus, 7alpha-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity." PMID: 17251929 (5)

6. Mechanism by which avenanthramide-c, a polyphenol of oats, blocks cell cycle progression in vascular smooth muscle cells.
Nie L, Wise M, Peterson D, Meydani M. Vascular Biology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

Previously, we reported that avenanthramide-c (Avn-c), one of the major avenanthramides, polyphenols of oats, inhibited the serum-induced proliferation of vascular smooth muscle cells (SMC), which is an important process in the initiation and development of atherosclerosis. In the present study, we further investigated its cell cycle inhibitory mechanism. Rat embryonic aortic smooth muscle cell line A10 was used in this study. Flow cytometry analysis revealed that treatment of A10 cells with 80 muM Avn-c arrested the cell cycle in G1 phase as indicated by an increase in the number of cells in G1 phase and a decrease in the number of cells in S phase. This cell cycle arrest was associated with a decrease in the phosphorylation of retinoblastoma protein (pRb), whose hyperphosphorylation is a hallmark of the G1 to S transition in the cell cycle. The inhibition of pRb phosphorylation with Avn-c was accompanied by a decrease in cyclin D1 expression and an increase in cyclin-dependent kinase inhibitor p21cip1 expression, without significant changes in p27kip1 expression. Furthermore, Avn-c treatment increased the expression level and stability of p53 protein, which could account for the increase of p21cip1 expression. Our results demonstrate for the first time that Avn-c, which is a unique polyphenol found in oats, arrests SMC proliferation at G1 phase by upregulating the p53-p21cip1 pathway and inhibiting pRB phosphorylation. This inhibitory effect of Avn-c on SMC proliferation is an additional indication for the potential health benefit of oat consumption in the prevention of coronary heart disease beyond its known effect through lowering blood cholesterol."PMID: 16895790 (6)

6. Physicochemical and hypocholesterolemic characterization of oxidized oat beta-glucan. Park SY, Bae IY, Lee S, Lee HG.Department of Food and Nutrition, Hanyang University, Haengdang-dong, Seongdong-gu, Seoul, Korea.

2,2,6,6-Tetramethyl-1-piperidine oxoammonium ion (TEMPO)-mediated oxidation was applied to oat beta-glucans, and the physicochemical and hypocholesterolemic properties of the resulting derivatives were investigated. The (13)C NMR spectra revealed that C6 primary alcohol groups were selectively oxidized into carboxyl groups. The oxidized derivatives exhibited enhanced water solubility and improved in vitro bile acid binding capacity. When hypercholesterolemic rats were fed diets containing the oxidized beta-glucan, the levels of triglyceride, total cholesterol, LDL-C, and VLDL-C in the rats significantly decreased (p < 0.05), consequently improving the serum lipid profiles. Dietary supplementation with beta-glucans reduced also the total cholesterol level in liver. Furthermore, more fecal eliminations of total cholesterol and triglyceride were observed, which were favorably correlated to their reduced levels in the serum and liver. As a result, oxidized oat beta-glucan exhibits potential use as an active cholesterol-lowering ingredient." PMID: 19119839 (7)

1 http://www.penispills.info/ingredient_list.html
2 http://www.ars.usda.gov/research/publications/publications.htm?seq_no_115=177702
3

PMID: 19230737

4 PMID: 18301937
5 PMID: 17251929
6 PMID: 16895790
7 PMID: 19119839
   
   
   
   
 
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